自纽约事件以来,托尼·斯塔克(小罗伯特·唐尼 Robert Downey Jr. 饰)为前所未有的焦虑症所困扰。他疯狂投入钢铁侠升级版的研发,为此废寝忘食,甚至忽略了女友佩珀·波茨(格温妮斯·帕特洛 Gwyneth Paltrow 饰)的感受。与此同时,臭名昭著的恐怖头目曼达林(本·金斯利 Ben Kingsley 饰)制造了一连串的爆炸袭击事件,托尼当年最忠诚的保镖即在最近的一次袭击中身负重伤。未过多久,托尼、佩珀以及曾与他有过一面之缘的女植物学家玛雅(丽贝卡·豪尔 Rebecca Hall 饰)在家中遭到猛烈的炮火袭击,几乎丧命,而这一切似乎都与22年前那名偶然邂逅的科学家阿尔德里奇·基连(盖·皮尔斯 Guy Pearce 饰)及其终极生物的研究有关。
即使有精密先进的铠甲护身,也无法排遣发自心底的焦虑。被击碎一切的托尼,如何穿越来自地狱的熊熊烈火……
In the year 2961, the time is after humanity and nature has recovered the land. A hunter named Cygnus is called to rise above his duty. He provides for Last Arc, a once nomadic band of survivors in need of food and water that is now growing scarce. The answer must be found before a group of outlandish Heretics descend upon them. Cygnus must voyage across the treacherous landscape to defend his people. Sent by Nova, the matriarch of the band, she acts based on her vision for Cygnus to find a seed of hope. The future of Last Arc is for him to discover, Cygnus ventures into a hostile landscape in search of an answer for his people. On this journey of encountering many traps and dangers, Cygnus discovers what has been hunting him is his identity.
时为1982年,一支隶属挪威的三人南极科考队在冰原中行进,意外发现一艘一百万年前的奇怪船只,并且在附近找到了冻于严冰之中的神秘生物。才貌双全的美国古生物学家凯特·洛伊德(玛丽·伊丽莎白·文斯蒂德 Mary Elizabeth Winstead 饰)在桑德尔·哈沃森博士(Ulrich Thomsen 饰)的邀请下,随同一众科研工作者前往南极。经过认真研究,他们发现这是地球上从未有过的生物。正当科学家们为了这个伟大的发现载歌载舞庆祝之时,神秘生物悄悄解冻,继而向人类展开凶残的袭击。经过一番惨烈的搏斗,怪物最终葬身火海。
但是厄运并未就此结束,经过对怪物细胞的观测,凯特隐隐感到一场灾难正向全人类袭来……